This study analyzed the effect of tertiary entrepreneurship courses on the career development competency of Technical University students. For that purpose, after conducting several face-to-face interactions of tertiary entrepreneurship course education for the past students of Bolgatanga Technical University, an empirical analysis was conducted based on 129 questionnaires. The results of the study are as follows. First, in this study, it was found that tertiary entrepreneurship courses had a positive effect on the career development competency of students and also on both the career design and pioneer drive, which are sub-factors of career development competency. Second, after the tertiary entrepreneurship course education was conducted, both entrepreneurship and career development competency were found to have improved, and in particular, the improvement of entrepreneurship was greater than that of career development competency. The study suggests that entrepreneurship education, focused on college students and adults, can be an effective career education program for adolescents in the second cycle system.